کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10823958 | 1061955 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Monoclonal B-cell hyperplasia and leukocyte imbalance precede development of B-cell malignancies in uracil-DNA glycosylase deficient mice
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کلمات کلیدی
TDGNei-likeNEILSMUG1MBD4UngActivation-induced cytidine deaminaseDLBCLCSRSHMThymine DNA glycosylase - DNA تلقیح گلیکوزیلازsomatic hypermutation - ابرمتن سوتیclass switch recombination - بازوی سوئیچ کلاسLymphoma - لنفومDiffuse large B-cell lymphoma - لنفوم سلول B بزرگ سلول بزرگFollicular lymphoma - لنفوم فولیکولارAID - کمکUracil-DNA glycosylase - گلوکوزیلاز اوراسیل DNA
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Ung-deficient mice have reduced class switch recombination, skewed somatic hypermutation, lymphatic hyperplasia and a 22-fold increased risk of developing B-cell lymphomas. We find that lymphomas are of follicular (FL) and diffuse large B-cell type (DLBCL). All FLs and 75% of the DLBCLs were monoclonal while 25% were biclonal. Monoclonality was also observed in hyperplasia, and could represent an early stage of lymphoma development. Lymphoid hyperplasia occurs very early in otherwise healthy Ung-deficient mice, observed as a significant increase of splenic B-cells. Furthermore, loss of Ung also causes a significant reduction of T-helper cells, and 50% of the young Ungâ/â mice investigated have no detectable NK/NKT-cell population in their spleen. The immunological imbalance is confirmed in experiments with spleen cells where the production of the cytokines interferon γ, interleukin 6 and interleukin 2 is clearly different in wild type and in Ung-deficient mice. This suggests that Ung-proteins, directly or indirectly, have important functions in the immune system, not only in the process of antibody maturation, but also for production and functions of immunologically important cell types. The immunological imbalances shown here in the Ung-deficient mice may be central in the development of lymphomas in a background of generalised lymphoid hyperplasia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: DNA Repair - Volume 4, Issue 12, 8 December 2005, Pages 1432-1441
Journal: DNA Repair - Volume 4, Issue 12, 8 December 2005, Pages 1432-1441
نویسندگان
Sonja Andersen, Madelene Ericsson, Hong Yan Dai, Javier Peña-Diaz, Geir Slupphaug, Hilde Nilsen, Harald Aarset, Hans E. Krokan,