دانلود مقالات ISI درباره ابرمتن سوتی + ترجمه فارسی

عوارض غیر عفونی در بیماران مبتلا به کمبود ایمنی متغیر در کودکان مبتلا به نقص های فوقانی جهش سوپنتی، اما نه در نوکلئوتیدی کلاس سوئیچ

Noninfectious complications in patients with pediatric-onset common variable immunodeficiency correlated with defects in somatic hypermutation but not in class-switch recombination

Keywords: ابرمتن سوتی; Common variable immunodeficiency; somatic hypermutation; class-switch recombination; hypermutation; pediatric; switch; AICDA; Activation-induced cytidine deaminase; Bcl-6; B-cell lymphoma 6; CSR; Class-switch recombination; CT; Circle transcript; CVID; Co

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

بلوغ وابستگی آنتی بادیهای ضد (4-هیدروکسی-3-نیترفنیل) استیل با مدولاسیون خاصیت آنتی ژن همراه است

Affinity maturation of anti-(4-hydroxy-3-nitrophenyl)acetyl antibodies accompanies a modulation of antigen specificity

Keywords: ابرمتن سوتی; NP; (4-hydroxy-3-nitrophenyl)acetyl; NIP; (4-hydroxy-3-iodo-5-nitrophenyl)acetyl; NNP; (4-hydroxy-3,5-dinitrophenyl)acetyl; CDR; complementarity determining region; SHM; somatic hypermutation; HEL; hen egg lysozyme; Ka; equilibrium associa tion constant;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

وضعیت جهش ایمونوگلوبولین ها در بیماران مبتلا به لوسمی لنفوسیتی مزمن: معنی و پیش آگهی

El estado mutacional de las inmunoglobulinas en pacientes con leucemia linfocítica crónica: significado y pronóstico

Keywords: ابرمتن سوتی; Leucemia linfocítica crónica; Hipermutación somática; Inmunoglobulinas; PronósticoChronic lymphocytic leukaemia; Somatic hypermutation; Immunoglobulin mutation; Prognosis

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

هیدرومیت سوکتی در ایمنی و سرطان: تجزیه و تحلیل بحران امضاهای جهش ریشه و حاوی کدون

Somatic hypermutation in immunity and cancer: Critical analysis of strand-biased and codon-context mutation signatures

Keywords: ابرمتن سوتی; AID; activation induced cytidine deaminase a APOBEC family member of DNA/RNA C-to-U editors and viral/transposon restriction factors; AP; apurinic or apyrimidinic site as a result of Base Excision Repair (BER); APE; AP endonuclease causes cleavage of the

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2016 سفارش ترجمه

دینامیک اپی ژنتیکی در ایمنی و خود ایمنی

Epigenetic dynamics in immunity and autoimmunity

Keywords: ابرمتن سوتی; Epigenetic dynamics; Immune system; Autoimmune diseases; DNA methylation; Histone modifications; DNMT; DNA methyltransferase; TET; ten-eleven translocation; AID/AICDA; activation-induced cytidine deaminase; APOBEC; Apolipoprotein B mRNA editing enzyme; BE

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

صفحه نمایش پستان برای کشف و بهینه سازی درمان های آنتی بادی

Mammalian cell display for the discovery and optimization of antibody therapeutics

Keywords: ابرمتن سوتی; Antibody; Somatic hypermutation; Mammalian cell display; AID;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

APOBEC and ADAR deaminases may cause many single nucleotide polymorphisms curated in the OMIM database

Keywords: ابرمتن سوتی; A>>T; SNPs or mutations of A exceed SNPs or mutations of T; ADAR; Adenosine Deaminase that acts on RNA. There are two main isoformsADAR1 and ADAR2 that have similar WA targeting specificity; AID; activation induced cytidine deaminase, an APOBEC family mem

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2018 سفارش ترجمه

JH6 downstream intronic sequence is dispensable for RNA polymerase II accumulation and somatic hypermutation of the variable gene in Ramos cells

Keywords: ابرمتن سوتی; AID; activation-induced deaminase; Pol II; RNA polymerase II; SHM; somatic hypermutation; Immunoglobulin; Variable gene; Somatic hypermutation; RNA polymerase II;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

Intra-seasonal antibody repertoire analysis of a subject immunized with an MF59®-adjuvanted pandemic 2009 H1N1 vaccine

Keywords: ابرمتن سوتی; AA; amino acid; Ab; antibody; BCR; B cell receptor; B-mAbs; biotinylated monoclonal antibodies; BSA; bovine serum albumin; CL; clonal lineage; CVV; candidate vaccine virus; DHVI; Duke Human Vaccine Institute; DPBS; Dulbecco's Phosphate-Buffered Saline;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

Immunoglobulin heavy chain variable region analysis in dairy goats

Keywords: ابرمتن سوتی; Ig; immunoglobulin; VH; immunoglobulin heavy chain variable region variable gene; DH; immunoglobulin heavy chain variable region diversity gene; JH; immunoglobulin heavy chain variable region joining gene; V(D)J; junction of immunoglobulin heavy chain var

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

miRNA meets plasma cells “How tiny RNAs control antibody responses”

Keywords: ابرمتن سوتی; PC; plasma cell; PB; plasmablast; GC; germinal center; SHM; somatic hypermutation; CSR; class switch recombination; AID; activation-induced cytidine deaminase; Ig; immunoglobulin; Blimp-1; B-lymphocyte-induced maturation protein 1; DGCR8; DiGeorge syndrom

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2018 سفارش ترجمه

A synthetic stroma-free germinal center niche for efficient generation of humoral immunity ex vivo

Keywords: ابرمتن سوتی; Synthetic germinal center; B cell; CD40L; Antigen specificity; Somatic hypermutation;

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2018 سفارش ترجمه

Endogenously generated DNA nucleobase modifications source, and significance as possible biomarkers of malignant transformation risk, and role in anticancer therapy

Keywords: ابرمتن سوتی; ROS; reactive oxygen species; 8-oxoGua; 8-Oxo-7,8-dihydroguanine; UNG; uracil-DNA glycosylase; TET; ten-eleven translocation protein; 5-mCyt; 5-Methylcytosine; 5-hmCyt; 5-Hydroxymethylcytosine; 5-fCyt; 5-formylcytosine; 5-caCyt; 5-Carboxycytosine; BER; ba

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2018 سفارش ترجمه

Random walks on binary strings applied to the somatic hypermutation of B-cells

Keywords: ابرمتن سوتی; Random walks on graphs; Hypercube; Hitting time; Mutational model; Evolutionary landscape; Somatic hypermutation;

دانلود رایگان متن کامل مقاله ISI 52 صفحه سال انتشار : 2018 سفارش ترجمه

Activation-induced deoxycytidine deaminase: Structural basis for favoring WRC hot motif specificities unique among APOBEC family members

Keywords: ابرمتن سوتی; AID; activation-induced deoxycytidine deaminase; SHM; somatic hypermutation; CSR; class switch recombination; Apo3A; APOBEC3A; AID X-ray crystal structure; C-deamination motif selectivity; Antibody diversity; IgV somatic hypermutation;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

ADAR deaminase A-to-I editing of DNA and RNA moieties of RNA:DNA hybrids has implications for the mechanism of Ig somatic hypermutation

Keywords: ابرمتن سوتی; A>>T; mutations of A exceed mutations of T, e.g. as found in normal murine physiological SHM in vivo by 2.9 fold; Aag; alkyladenine DNA glycosylase; ADAR; Adenosine Deaminase that acts on RNA; AID; activation induced cytidine deaminase, a APOBEC family me

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

SRSF1-3 contributes to diversification of the immunoglobulin variable region gene by promoting accumulation of AID in the nucleus

Keywords: ابرمتن سوتی; AID; DT40; Gene conversion; Ig; Somatic hypermutation; SRSF1; AID; activation-induced cytidine deaminase; AIDΔC; C-terminal 10 amino acid-deleted AID; CSR; class switch recombination; GCV; gene conversion; IgV; immunoglobulin variable region; NES; nuclea

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Follicular lymphoma (FL): Immunological tolerance theory in FL

Keywords: ابرمتن سوتی; Autoimmunity; Clonal selection theory; Tolerance mechanisms; Follicular lymphoma; Receptor editing; Somatic hypermutation;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

R-Loop Depletion by Over-expressed RNase H1 in Mouse B Cells Increases Activation-Induced Deaminase Access to the Transcribed Strand without Altering Frequency of Isotype Switching

Keywords: ابرمتن سوتی; R-loops; somatic hypermutation; class switch recombination; RNase H1; transgenic mouse; CSR; class switch recombination; SHM; somatic hypermutation; Tg; transgenic; TCR; T-cell receptor; LPS; lipopolysaccharide; IL4; interleukin 4; pol II; polymerase II;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

ReviewRNA Exosome and Non-coding RNA-Coupled Mechanisms in AID-Mediated Genomic Alterations

Keywords: ابرمتن سوتی; AID; activation-induced cytidine deaminase; CSR; class switch recombination; SHM; somatic hypermutation; Ag; antigen; Ig; immunoglobulin; BCR; B-cell Ag receptor; hs; DNase hypersensitive site; ncRNA; non-coding RNA; S; switch; SE; super-enhancer; DSB; do

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

CD11b regulates antibody class switching via induction of AID

Keywords: ابرمتن سوتی; ITGAM; integrin subunit alpha M; SLE; systemic lupus erythematosus; CSR; class switch recombination; AID; activation induced cytidine deaminase; TLR; Toll-like receptor; BCR; B cell receptors; SHM; somatic hypermutation; CFSE; carboxyfluorescein succinimi

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

Somatic hypermutation of immunoglobulin genes in Rad18 knockout mice

Keywords: ابرمتن سوتی; Somatic hypermutation; Immunoglobulin; Rad18; PCNA; DNA polymerase;

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2017 سفارش ترجمه

Activation induced cytidine deaminase mutant (AID-His130Pro) from Hyper IgM 2 patient retained mutagenic activity on SHM artificial substrate

Keywords: ابرمتن سوتی; Activation induced cytidine deaminase; Class switch recombination; Somatic hypermutation; AID mutagenic activity; Cofactors; Hyper IgM 2;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Antibody diversification caused by disrupted mismatch repair and promiscuous DNA polymerases

Keywords: ابرمتن سوتی; AID; activation-induced deaminase; APE; apurinic/apyrimidinic endonuclease; BER; base excision repair; bp; base pair; CSR; class switch recombination; D; diversity gene segment; EXO1; exonuclease 1; Ig; immunoglobulin; J; joining gene segment; pol; polyme

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Structural analysis of the activation-induced deoxycytidine deaminase required in immunoglobulin diversification

Keywords: ابرمتن سوتی; AID; activation induced deoxycytidine deaminase; SHM; somatic hypermutation; CSR; class switch recombination; Apo3A; APOBEC3A; Apo3G; APOBEC3G; HIGM-2; Hyper IgM syndrome type 2; AID X-ray crystal structure; Antibody diversity; IgV somatic hypermutation;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

B cell development in chromosome 22q11.2 deletion syndrome

Keywords: ابرمتن سوتی; DiGeorge syndrome; Follicular helper T cells; Somatic hypermutation; TBX1; Immunoglobulin; 22q11.2 deletion syndrome; Switched memory B cells;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Contribution of secondary Igkappa rearrangement to primary immunoglobulin repertoire diversification

Keywords: ابرمتن سوتی; RSS; recombination signal sequence; BCR; B-cell antigen receptors; Ag; antigen; cRS; cryptic recombination signal; FWR; framework region; SE; signal end; CDR3; complementarity-determining region 3; Ab; antibody; SHM; somatic hypermutation; AID; activation

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2016 سفارش ترجمه

Immune deficiencies, infection, and systemic immune disordersDefects of B-cell terminal differentiation in patients with type-1 Kabuki syndrome

Keywords: ابرمتن سوتی; Kabuki syndrome; KMT2D; KDM6A; hypogammaglobulinemia; memory B cells; CD21lo B cells; class-switch recombination; somatic hypermutation; PTIP; AICDA; AID; polymerase eta; AICDA; Activation-induced cytidine deaminase; cKS; Clinical Kabuki syndrome (no iden

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2016 سفارش ترجمه

Amplification of highly mutated human Ig lambda light chains from an HIV-1 infected patient

Keywords: ابرمتن سوتی; Anti-HIV-1 antibodies; Single cell sorting; Human Ig lambda; Somatic hypermutation; PCR

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Topoisomerase I deficiency causes RNA polymerase II accumulation and increases AID abundance in immunoglobulin variable genes

Keywords: ابرمتن سوتی; DT40; Topoisomerase I; RNA polymerase II; Activation-induced deaminase; Somatic hypermutation; Gene conversion;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

B cell Variable genes have evolved their codon usage to focus the targeted patterns of somatic mutation on the complementarity determining regions

Keywords: ابرمتن سوتی; Somatic hypermutation; Codon usage; Affinity maturation; Evolution; Codon bias; B cells

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

High affinity IgM+ memory B cells are generated through a germinal center-dependent pathway

Keywords: ابرمتن سوتی; Germinal center reaction; Somatic hypermutation; Class switch recombination; Affinity maturation; IgM

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

The bilateral responsiveness between intestinal microbes and IgA

Keywords: ابرمتن سوتی; IgA; commensal microbiota; germinal centres; somatic hypermutation; follicular helper T cells; follicular regulatory T cells; follicular dendritic cells; Peyer's patch; isolated lymphoid follicles;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Predominant role for activation-induced cytidine deaminase in generating IgG anti-nucleosomal antibodies of murine SLE

Keywords: ابرمتن سوتی; Lupus; Anti-nuclear; Autoantibodies; Somatic hypermutation

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

ReviewMammalian cell display technology coupling with AID induced SHM in vitro: An ideal approach to the production of therapeutic antibodies

Keywords: ابرمتن سوتی; Mammalian cell display; Activation-induced cytidine deaminase; Somatic hypermutation; Therapeutic antibody;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Glucocorticoid inhibition of activation-induced cytidine deaminase expression in human B lymphocytes

Keywords: ابرمتن سوتی; Glucocorticoids; B Lymphocytes; Activation-induced cytidine deaminase; Class switch recombination; Somatic hypermutation;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

De novo oligoclonal expansions of circulating plasmablasts in active and relapsing IgG4-related disease

Keywords: ابرمتن سوتی; IgG4-related disease; autoreactivity; rituximab; next-generation sequencing; somatic hypermutation; plasmablasts; immunoglobulin heavy chain variable region repertoire; CDR3; IgG4-RD; IgG4-related disease; IGHV; Immunoglobulin heavy chain variable region;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Contributions of B cells to lupus pathogenesis

Keywords: ابرمتن سوتی; Ab; antibody; AFC; antibody forming cells; BCR; B cell receptor; DC; dendritic cell; GC; germinal center; IC; immune complex; ICOS; inducible T cell co-stimulator; PC; plasma cell; SLE; systemic lupus erythematosus; Tg; transgenic; Ag; antigen; MZ; margin

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Characteristics of the somatic hypermutation in the Camelus dromedarius T cell receptor gamma (TRG) and delta (TRD) variable domains

Keywords: ابرمتن سوتی; T cell receptor; TRG and TRD genes; Somatic hypermutation; Dromedary; IMGT

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2014 سفارش ترجمه

Activation-induced cytidine deaminase (AID) is localized to subnuclear domains enriched in splicing factors

Keywords: ابرمتن سوتی; AID; activation-induced cytidine deaminase; CB; Cajal body; CTNNBL1; catenin-β-like protein 1; CSR; class switch recombination; Fib; fibrillarin; LeptB; leptomycin B; NLS; nuclear localization signal; SC35; 35 kD serine/arginine-rich splicing factor 2; S

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2014 سفارش ترجمه

Immune deficiencies, infection, and systemic immune disordersDefective B-cell memory in patients with Down syndrome

Keywords: ابرمتن سوتی; Down syndrome; common variable immunodeficiency; antibody; B cell; selection; somatic hypermutation; IgM; IgA; plasma cell; AID; Activation-induced cytidine deaminase; BAFF; B cell-activating factor; CDR; Complementarity-determining region; CVID; Common

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2014 سفارش ترجمه

Accumulation of Somatic Mutations in TP53 in Gastric Epithelium With Helicobacter pylori Infection

Keywords: ابرمتن سوتی; Stomach Cancer; Somatic Hypermutation; Pathogenesis; Bacteria; AID; activation-induced cytidine deaminase; Hupki; human TP53 knock-in; indel; insertion and deletion; MSI; microsatellite instability; MSS; microsatellite stability; PCR; polymerase chain rea

دانلود رایگان متن کامل مقاله ISI 85 صفحه سال انتشار : 2014 سفارش ترجمه

PCR amplification and high throughput sequencing of immunoglobulin heavy chain genes from formalin-fixed paraffin-embedded human biopsies

Keywords: ابرمتن سوتی; FFPE tissues; formalin-fixed paraffin-embedded tissues; HTS; high throughput sequencing; Ig; immunoglobulin; MID; multiplex identifier; SHM; somatic hypermutation; Formalin-fixed paraffin-embedded tissues; High throughput sequencing; Ig variable region ge

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Multiple microRNAs may regulate the DNA repair enzyme uracil-DNA glycosylase

Keywords: ابرمتن سوتی; 3′UTR; 3′untranslated region; AID; activation-induced cytidine deaminase; ATM; mutated in ataxia teleangiectasia; BER; base excision repair; CLL; chronic lymphocytic leukemia; CSR; class-switch recombination; miRNA; microRNA; MMR; mismatch repair; NER

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Brief CommunicationA novel activation-induced cytidine deaminase (AID) mutation in Brazilian patients with hyper-IgM type 2 syndrome

Keywords: ابرمتن سوتی; AID; activation-induced cytidine deaminase; wt; wild type; SHM; somatic hypermutation; CSR; class switch recombination; APOBEC1; apolipoprotein B mRNA editing catalytic polypeptide 1; GC; gene conversion; NES; nuclear export signal; NLS; nuclear localizat

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

B-cell biology and development

Keywords: ابرمتن سوتی; B cell; B lymphocyte; immunodeficiency; development; humoral immunity; autoimmunity; tolerance; AID; Activation-induced cytidine deaminase; APRIL; A proliferation-inducing ligand; BAFF; B-cell activator of the TNF-α family (aka BLYS); BAFF-R; BAFF recept

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

B-lymphocyte lineage cells and the respiratory system

Keywords: ابرمتن سوتی; B cells; plasma cells; plasmablasts; respiratory diseases; AID; Activation-induced cytidine deaminase; APRIL; A proliferation-inducing ligand; BAFF; B cell-activating factor of the TNF family; BAL; Bronchoalveolar lavage; BCMA; B-cell maturation antigen

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2013 سفارش ترجمه

The importance of codon context for understanding the Ig-like somatic hypermutation strand-biased patterns in TP53 mutations in breast cancer

Keywords: ابرمتن سوتی; TP53; codon-bias; breast cancer; somatic hypermutation; mutagenesis

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Analysis of cellular phenotype during in vitro immunization of murine splenocytes for generating antigen-specific immunoglobulin

Keywords: ابرمتن سوتی; In vitro immunization; Activation-induced cytidine deaminase; Germinal center; Somatic hypermutation; T cell dependent stimuli

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Antibody repertoire development in fetal and neonatal piglets. XIV. Highly restricted IGKV gene usage parallels the pattern seen with IGLV and IGHV

Keywords: ابرمتن سوتی; Light chain; Swine; Transcription; Somatic hypermutation; CDR3 diversity

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه