کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8429342 | 1546203 | 2018 | 43 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Endogenously generated DNA nucleobase modifications source, and significance as possible biomarkers of malignant transformation risk, and role in anticancer therapy
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کلمات کلیدی
ESCODDOGG1LSD1dUTPase8-oxodGMMRTDGBERTETSHMUng8-oxoGuaHSCAML5-carboxycytosine5-Hydroxymethyluracil - 5- Hydroxymethyluracil5-formylcytosine - 5-فرمیل سیتوزین5-Methylcytosine - 5-متیل سیتوزین5-hydroxymethylcytosine - 5-هیدروکسی متیل سیتوزین8-oxo-7,8-dihydroguanine - 8-اکسو-7،8-دی هیدروگوانین8-oxoguanine DNA glycosylase 1 - 8-اکسوگوئین دی ان ای گلیکوزیلاز 1Thymine DNA glycosylase - DNA تلقیح گلیکوزیلازROS - ROSDNA damage - آسیبDNAsomatic hypermutation - ابرمتن سوتیlysine-specific demethylase 1 - الکل دیمیتیلاز 1DNA repair - ترمیم DNAmismatch repair - تعمیر ناسازگاریbase excision repair - تعمیر پایه پایهOxidative stress - تنش اکسیداتیوCancer - سرطانhematopoietic stem cells - سلول های بنیادی خونسازactivation-induced cytosine deaminase - فعال سازی ناشی از سیتوزین دامینازacute myeloid leukemia - لوسمی حاد میلوئیدی یا به اختصار AMLMethylation - متیلاسیونBiomarkers - نشانگر زیستی یا بیومارکرAID - کمکUracil-DNA glycosylase - گلوکوزیلاز اوراسیل DNAReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Endogenously generated DNA nucleobase modifications source, and significance as possible biomarkers of malignant transformation risk, and role in anticancer therapy Endogenously generated DNA nucleobase modifications source, and significance as possible biomarkers of malignant transformation risk, and role in anticancer therapy](/preview/png/8429342.png)
چکیده انگلیسی
The DNA of all living cells undergoes continuous structural and chemical alteration, which may be derived from exogenous sources, or endogenous, metabolic pathways, such as cellular respiration, replication and DNA demethylation. It has been estimated that approximately 70,000 DNA lesions may be generated per day in a single cell, and this has been linked to a wide variety of diseases, including cancer. However, it is puzzling why potentially mutagenic DNA modifications, occurring at a similar level in different organs/tissue, may lead to organ/tissue specific cancers, or indeed non-malignant disease - what is the basis for this differential response? We suggest that it is perhaps the precise location of damage, within the genome, that is a key factor. Finally, we draw attention to the requirement for reliable methods for identification and quantification of DNA adducts/modifications, and stress the need for these assays to be fully validated. Once these prerequisites are satisfied, measurement of DNA modifications may be helpful as a clinical parameter for treatment monitoring, risk group identification and development of prevention strategies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer - Volume 1869, Issue 1, January 2018, Pages 29-41
Journal: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer - Volume 1869, Issue 1, January 2018, Pages 29-41
نویسندگان
Ryszard Olinski, Daniel Gackowski, Marcus S. Cooke,