Maxadilan, the Lutzomyia longipalpis vasodilator, drives plasma leakage via PAC1-CXCR1/2-pathway

► Maxadilan and PACAP-38 caused plasma leakage and leukocyte accumulation in postcapillary venules. ► Neutrophil migration induced by maxadilan was inhibited by PAC1- and CXCR2-antagonists. ► Four drugs with different mechanism of action inhibited both plasma leakage and leukocyte accumulation. ► A positive linear correlation between plasma leakage and leukocyte accumulation was observed during 30 min after its initiation.