Toluene impairs learning and memory, has antinociceptive effects, and modifies histone acetylation in the dentate gyrus of adolescent and adult rats

► Toluene impairs learning, short- and long-term memory in adolescent and adult rats. ► Toluene produces antinociception in rats and tolerance develops to this effect. ► Acute and chronic toluene exposure alters the hippocampal histone acetylation pattern.