Reversal of scopolamine-induced disruption of prepulse inhibition by clozapine in mice

► Prepulse inhibition is disrupted by muscarinic cholinergic blocker in mice. ► The effect is centrally mediated and independent of its effect on startle reactivity. ► Clozapine antagonizes the PPI-disruptive effect of scopolamine. ► A drug-induced PPI deficit model uniquely responsive to typical/atypical neuroleptics.