Neuroprotective effect of RO-20-1724-a phosphodiesterase4 inhibitor against intracerebroventricular streptozotocin induced cognitive deficit and oxidative stress in rats

► Effect of PDE4 inhibition against streptozotocin (STZ) induced neurotoxicity. ► STZ produced cognitive dysfunction and increased oxidative stress in rats. ► RO-20-1724, a PDE4 inhibitor, attenuated STZ-induced neurotoxicity. ► PDE4 inhibition may be useful strategy to treat neurodegenerative disorders.