Effects of sleep deprivation on retrieval and reconsolidation of morphine reward memory in rats

► Sleep deprivation had no effect on the retrieval of morphine reward memory. ► Sleep deprivation from 0 - 6 h after re-exposure disrupted morphine reward memory. ► No aversive memory was found between the drug-paired context and sleep deprivation. ► Sleep deprivation may be a potential non-pharmacotherapy for relapse.