Lipoic acid inhibits caspase-dependent and -independent cell death pathways and is neuroprotective against hippocampal damage after pilocarpine-induced seizures

► α-lipoic acid reduced DNA fragmentation as indication of apoptosis after seizures. ► α-lipoic acid inhibited the caspase-dependent pathway after pilocarpine-induced seizures. ► α-lipoic acid inhibited the caspase-independent pathway after pilocarpine-induced seizures.