کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10872612 1074199 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Membrane protein assembly patterns reflect selection for non-proliferative structures
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Membrane protein assembly patterns reflect selection for non-proliferative structures
چکیده انگلیسی
Membrane proteins that regulate solute movement are often built from multiple copies of an identical polypeptide chain. These complexes represent striking examples of self-assembling systems that recruit monomers only until a prescribed level for function is reached. Here we report that three modes of assembly - distinguished by sequence and stoichiometry - describe all helical membrane protein complexes currently solved to high resolution. Using the 13 presently available non-redundant homo-oligomeric structures, we show that two of these types segregate with protein function: one produces energy-dependent transporters, while the other builds channels for passive diffusion. Given such limited routes to functional complexes, membrane proteins that self-assemble exist on the edge of aggregation, susceptible to mutations that may underlie human diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 581, Issue 7, 3 April 2007, Pages 1335-1341
نویسندگان
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