کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10883145 1078355 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Increased availability of endogenous and dietary oleic acid contributes to the upregulation of cardiac fatty acid oxidation
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوفیزیک
پیش نمایش صفحه اول مقاله
Increased availability of endogenous and dietary oleic acid contributes to the upregulation of cardiac fatty acid oxidation
چکیده انگلیسی
In the present study, we tested the hypothesis that cardiac substrate utilization is affected by oleic acid originating from the endogenous conversion of stearate by stearoyl-CoA desaturase and from the diet. Here, we show that the cardiac oleate content is increased in tristearate (TS)- and trioleate (TO)-fed rats when compared with chow-fed rats. TS or TO feeding increases mitochondrial fatty acid oxidation via activation of expression of the oxidative genes, activation of the AMP-activated protein kinase pathway, and a decrease in glucose uptake. These results suggest that oleic acid, both dietary and de novo synthesized, affects substrate utilization in the heart. Furthermore, our data show that the endogenous synthesis of oleate in the heart can compensate for a deficiency of this fatty acid in the diet.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mitochondrion - Volume 12, Issue 1, January 2012, Pages 132-137
نویسندگان
, , , ,