کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10903994 1086547 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Function of transcription factors at DNA lesions in DNA repair
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Function of transcription factors at DNA lesions in DNA repair
چکیده انگلیسی
Cellular systems for DNA repair ensure prompt removal of DNA lesions that threaten the genomic stability of the cell. Transcription factors (TFs) have long been known to facilitate DNA repair via transcriptional regulation of specific target genes encoding key DNA repair proteins. However, recent findings identified TFs as DNA repair components acting directly at the DNA lesions in a transcription-independent fashion. Together this recent progress is consistent with the hypothesis that TFs have acquired the ability to localize DNA lesions and function by facilitating chromatin remodeling at sites of damaged DNA. Here we review these recent findings and discuss how TFs may function in DNA repair.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Cell Research - Volume 329, Issue 1, 15 November 2014, Pages 94-100
نویسندگان
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