کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10904001 1086547 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Blurring the line between the DNA damage response and transcription: The importance of chromatin dynamics
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Blurring the line between the DNA damage response and transcription: The importance of chromatin dynamics
چکیده انگلیسی
DNA damage interferes with the progression of transcription machineries. A tight coordination of transcription with signaling and repair of DNA damage is thus critical for safeguarding genome function. This coordination involves modulations of chromatin organization. Here, we focus on the central role of chromatin dynamics, in conjunction with DNA Damage Response (DDR) factors, in controlling transcription inhibition and restart at sites of DNA damage in mammalian cells. Recent work has identified chromatin modifiers and histone chaperones as key regulators of transcriptional activity in damaged chromatin regions. Conversely, the transcriptional state of chromatin before DNA damage influences both DNA damage signaling and repair. We discuss the importance of chromatin plasticity in coordinating the interplay between the DDR and transcription, with major implications for cell fate maintenance.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Cell Research - Volume 329, Issue 1, 15 November 2014, Pages 148-153
نویسندگان
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