کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10904195 1086565 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chorion formation in panoistic ovaries requires windei and trimethylation of histone 3 lysine 9
ترجمه فارسی عنوان
تشکیل کوریون در تخمدانهای پانوسئیست نیاز به ویترینی و ترمیم کردن هیستون 3 لیزین 9 دارد
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی
Epigenetic modifications play key roles in transcriptional regulation. Trimethylation of histone 3 lysine 9 (H3K9me3) is one of the most widely studied histone post-translational modifications, and has been linked to transcriptional repression. In Drosophila melanogaster, Windei is needed for H3K9me3 in female germ line cells. Here, we report the occurrence of a D. melanogaster Windei (Wde) ortholog in the ovary of the hemimetabolous insect Blattella germanica, which we named BgWde. Depletion of BgWde by RNAi reduced H3K9me3 in follicular cells, which triggered changes in transcriptional regulation that led to the prevention of chorion gene expression. In turn, this impaired oviposition (and the formation of the ootheca) and, therefore, prevented reproduction. Windei and H3K9me3 have already been reported in follicular cells of D. melanogaster, but this is the first time that the function of these modifications has been demonstrated in the said cells. This is also the first time that an epigenetic marker is reported as having a key role in choriogenesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Cell Research - Volume 320, Issue 1, 1 January 2014, Pages 46-53
نویسندگان
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