The role of immune semaphorins in cancer progression

- SEMA3A restricts tumor progression while SEMA4D induce tumor progression.
- Tumor angiogenesis is induced by SEMA4D but inhibited by SEMA3A.
- T-cells are regulated by various immune SEMAs including SEMA3A, 4A, 6D and 7A.
- Macrophages express immune SEMAs including SEMA4A, 4D and 6D.
- Dendritic Cells express immune SEMAs including SEMA3A and 4A.