کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10904389 1086580 2013 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In vitro DNA-damaging effects of intestinal and related tetrapyrroles in human cancer cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
In vitro DNA-damaging effects of intestinal and related tetrapyrroles in human cancer cells
چکیده انگلیسی
► DNA-damaging effects of bile pigments have been rarely investigated. ► Thus, eight tetrapyrroles were tested for DNA-damaging effects in the comet assay. ► To assess DNA damage, cancer cells were used, and flow cytometry parameters were measured. ► Especially protoporphyrin, urobilin and stercobilin increased DNA strand breaks significantly. ► Mechanisms could include oxidative stress, cell cycle arrest and apoptosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Cell Research - Volume 319, Issue 4, 15 February 2013, Pages 536-545
نویسندگان
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