Bile acids activate ryanodine receptors in pancreatic acinar cells via a direct allosteric mechanism

- Bile acids trigger Ca2+ release in pancreatic acinar cells.
- The Ca2+ release is attenuated by the RyR inhibitor dantrolene.
- Bile acid taurocholate (TCA) directly opens RyR type 1.
- TCA inhibits SERCA activity.
- TCA may contribute to Ca2+ overload in pancreatitis by activating RyR directly.