Toll recognition signal activates oenocytoid cell lysis via a crosstalk between plasmatocyte-spreading peptide and eicosanoids in response to a fungal infection

► Plasmatocyte-spreading peptide (PSP) is an insect cytokine and induces. ► Fungal infection activates Toll signaling, which then activates PSP expression. ► PSP activates PLA2 to produce prostaglandins (PGs). ► PGs induce oenocytoid cell lysis (OCL), which release prophenoloxidase for activation.