Insulin modifies aging-related inhibition of 1-stearoyl, 2-arachidonoylglycerol phosphorylation in rat synaptic terminals

▶ PA synthesis from exogenous SAG was diminished in CC and Hp synaptosomes from aged rats. ▶ Aging decrease PI synthesis in synaptosomes from CC. ▶ Insulin differentially stimulates PA synthesis from exogenous SAG in CC and Hp synaptosomes from adult and aged rats. ▶ The inhibition of PI synthesis in CC synaptosomes from aged rats was found to be reverted by insulin.