کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10963001 | 1102663 | 2016 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A highly conserved epitope-vaccine candidate against varicella-zoster virus induces neutralizing antibodies in mice
ترجمه فارسی عنوان
یک کاندیدا واکسن اپیتوپسی بسیار محافظت شده علیه ویروس واریسلا-زوستر باعث ایجاد آنتی بادیهای خنثی در موش می شود
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
چکیده انگلیسی
Varicella-zoster virus (VZV) is a highly infectious agent of varicella and herpes zoster (HZ). Vaccination is by far the most effective way to prevent these diseases. More safe, stable and efficient vaccines, such as epitope-based vaccines, now have been increasingly investigated by many researchers. However, only a few VZV neutralizing epitopes have been identified to date. We have previously identified a linear epitope between amino acid residues 121 and 135 of gE. In this study, we validated that this epitope is highly conserved amongst different VZV strains that covered five existing phylogenetic clades with an identity of 100%. We evaluated the immunogenicity of the recombinant hepatitis B virus core (HBc) virus-like particles (VLPs) which included amino acids (121-135). VZV-gE-specific antibodies were detected in immunized mouse serum using ELISA. The anti-peptide antiserum positively detected VZV via Western blot and immunofluorescent staining assays. More importantly, these peptides could neutralize VZV, indicating that these peptides represented neutralizing epitopes. These findings have important implications for the development of epitope-based protective VZV vaccines.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 34, Issue 13, 18 March 2016, Pages 1589-1596
Journal: Vaccine - Volume 34, Issue 13, 18 March 2016, Pages 1589-1596
نویسندگان
Rui Zhu, Jian Liu, Chunye Chen, Xiangzhong Ye, Longfa Xu, Wei Wang, Qinjian Zhao, Hua Zhu, Tong Cheng, Ningshao Xia,