کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10964087 1102702 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Requirement of immune system heterogeneity for protective immunity
ترجمه فارسی عنوان
نیاز به ناهمگنی سیستم ایمنی برای ایمنی محافظ
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
چکیده انگلیسی
Although our knowledge on the immune system and immunological memory has expanded enormously during the last decades, the development of strategies to induce robust protective memory against infections and tumors remains challenging. Intense efforts and immense resources have been put into the development of vaccines. However, effective tools to assess protective immunity, beyond neutralizing antibody titers and cytotoxic T cell activity, are still missing. Previous trials have primarily focused on individual cell subsets to induce and maintain protection while current research emphasizes the importance of functional heterogeneity and necessity of efficient communication within the immunological network. In this review, established knowledge as well as current perspectives on protective immunological memory will be discussed comprehensively.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 33, Issue 40, 29 September 2015, Pages 5308-5312
نویسندگان
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