Immunization of cows with novel core glycolipid vaccine induces anti-endotoxin antibodies in bovine colostrum

The J5dLPS/OMP vaccine elicits high titers of serum anti-endotoxin antibodies in cows that is passed to the colostrum. This BC enriched in anti-core LPS antibodies has the potential to reduce endotoxemia and ameliorate endotoxin-related systemic inflammation in patients with impaired gut barrier function. Since this vaccine is significantly more immunogenic than the J5 Bacterin® vaccine, this J5dLPS/OMP vaccine might prove to be more useful for veterinary indications as well.