کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10964715 1102724 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Modeling the durability of ZOSTAVAX® vaccine efficacy in people ≥60 years of age
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Modeling the durability of ZOSTAVAX® vaccine efficacy in people ≥60 years of age
چکیده انگلیسی
Since 2006, the vaccine, ZOSTAVAX®, has been licensed to prevent herpes zoster. Only limited clinical follow-up data are available to evaluate duration of protection, an important consideration when developing HZ vaccination policy recommendations. Four Poisson regression models were developed based on an integrated analysis of data from the Shingles Prevention Study and its Short Term Persistence extension to estimate the effects of years-since-vaccination and chronological-age on vaccine efficacy among people ≥60 years old. The models included number of HZ cases parsed into categories by chronological-age and time-since-vaccination as the dependent variable with different explanatory variables in each model. In all models, the interaction between vaccine-group and chronological-age was statistically significant indicating that vaccine efficacy decreases with the expected effects of advancing age but the interaction between vaccine-group and time-since-vaccination was not statistically significant indicating that much of the reduction in vaccine efficacy over time-since-vaccination can be explained by increasing age.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 33, Issue 12, 17 March 2015, Pages 1499-1505
نویسندگان
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