کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10964859 | 1102728 | 2015 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Protection of non-human primates against glanders with a gold nanoparticle glycoconjugate vaccine
ترجمه فارسی عنوان
حفاظت از اولیای غیر انسانی در برابر غدد لنفاوی با یک واکسن گلیکوکونژوگه نانوذره طلا
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
چکیده انگلیسی
The Gram-negative Burkholderia mallei is a zoonotic pathogen and the causative agent of glanders disease. Because the bacteria maintain the potential to be used as a biothreat agent, vaccine strategies are required for human glanders prophylaxis. A rhesus macaque (Macaca mulatta) model of pneumonic (inhalational) glanders was established and the protective properties of a nanoparticle glycoconjugate vaccine composed of Burkholderia thailandensis LPS conjugated to FliC was evaluated. An aerosol challenge dose of â¼1 Ã 104 CFU B. mallei produced mortality in 50% of naïve animals (n = 2/4), 2-3 days post-exposure. Although survival benefit was not observed by vaccination with a glycoconjugate glanders vaccine (p = 0.42), serum LPS-specific IgG titers were significantly higher on day 80 in 3 vaccinated animals who survived compared with 3 vaccinated animals who died. Furthermore, B. mallei was isolated from multiple organs of both non-vaccinated survivors, but not from any organs of 3 vaccinated survivors at 30 days post-challenge. Taken together, this is the first time a candidate vaccine has been evaluated in a non-human primate aerosol model of glanders and represents the initial step for consideration in pre-clinical studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 33, Issue 5, 29 January 2015, Pages 686-692
Journal: Vaccine - Volume 33, Issue 5, 29 January 2015, Pages 686-692
نویسندگان
Alfredo G. Torres, Anthony E. Gregory, Christopher L. Hatcher, Heather Vinet-Oliphant, Lisa A. Morici, Richard W. Titball, Chad J. Roy,