کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10965641 | 1102754 | 2014 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pre-clinical immunogenicity of human papillomavirus alpha-7 and alpha-9 major capsid proteins
ترجمه فارسی عنوان
ایمن سازگاری پیش از کلینیک پروتئین های کپسید اصلی آلفا 7 و آلفا 9 مهمترین پاپیلومای ویروس انسان است
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
چکیده انگلیسی
The majority antibody response against L1 VLP was type-specific, as expected, but several instances of robust cross-neutralization were nevertheless observed including between HPV33 and HPV58 within the Alpha-9 species and between HPV39, HPV59 and HPV68 in the Alpha-7 species. Immunization with an experimental tetravalent preparation comprising VLP based upon HPV16, HPV18, HPV39 and HPV58 was capable of generating neutralizing antibodies against all the Alpha-7 and Alpha-9 genotypes. Competition of HPV31 and HPV33 cross-neutralizing antibodies in the tetravalent sera confirmed that these antibodies originated from HPV16 and HPV58 VLP, respectively, and suggested that they represent minority specificities within the antibody repertoire generated by the immunizing antigen. These data improve our understanding of the antigenic diversity of the L1 protein per se and may inform the rational design of a next generation vaccine formulation based upon empirical data.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 32, Issue 48, 12 November 2014, Pages 6548-6555
Journal: Vaccine - Volume 32, Issue 48, 12 November 2014, Pages 6548-6555
نویسندگان
Sara L. Bissett, Giada Mattiuzzo, Eve Draper, Anna Godi, Dianna E. Wilkinson, Philip Minor, Mark Page, Simon Beddows,