کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10965912 | 1102763 | 2014 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Influenza M2 virus-like particles confer a broader range of cross protection to the strain-specific pre-existing immunity
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Immunity in humans with annual vaccination does not provide effective protection against antigenically distinct strains. As an approach to improve cross-protection in the presence of pre-existing strain-specific immunity, we investigated the efficacy of heterologous and heterosubtypic protection in previously vaccinated mice at earlier times after subsequent immunization with conserved-antigenic target influenza M2 ectodomain (M2e) virus-like particle vaccine (M2e5à VLP). Immunization of mice with H1N1 split vaccine induced virus specific antibodies to homologous influenza virus but did not provide heterosubtypic hemagglutination inhibiting antibody responses and cross-protection. However, subsequent M2e5à VLP immunization induced an M2e specific antibody response as well as interferon-γ (IFN-γ) producing cells in systemic and mucosal sites. Upon lethal challenge with H3N2 or H5N1 subtype influenza viruses, subsequently immunized mice with M2e5à VLP were well protected against heterosubtypic influenza viruses. These results provide evidence that non-seasonal immunization with M2e5à VLP, an experimental candidate for universal vaccine, is a promising approach for broadening the cross-protection even in the presence of strain-specific immunity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 32, Issue 44, 7 October 2014, Pages 5824-5831
Journal: Vaccine - Volume 32, Issue 44, 7 October 2014, Pages 5824-5831
نویسندگان
Min-Chul Kim, Yu-Na Lee, Hye Suk Hwang, Young-Tae Lee, Eun-Ju Ko, Yu-Jin Jung, Min Kyoung Cho, Yu-Jin Kim, Jong Seok Lee, Suk-Hoon Ha, Sang-Moo Kang,