کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10965998 | 1102765 | 2013 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Impact of MenBvac, an outer membrane vesicle (OMV) vaccine, on the meningococcal carriage
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Impact of MenBvac, an outer membrane vesicle (OMV) vaccine, on the meningococcal carriage Impact of MenBvac, an outer membrane vesicle (OMV) vaccine, on the meningococcal carriage](/preview/png/10965998.png)
چکیده انگلیسی
The aim of the study was to analyze the impact of MenBvac, an outer membrane vesicle (OMV) vaccine against P1.7,16 strains, on meningococcal carriage. During a B:14:P1.7,16/ST-32 outbreak in Normandy (France), children aged 1-7 years were randomly selected to participate in the study. Among the 1082 volunteers, there were 17 Neisseria meningitidis carriers (carriage rate of 1.57%). MenBvac vaccination appeared associated with lower carriage rate, i.e., 0.31% among the vaccinated children versus 2.10% among the non-vaccinated (p = 0.03). The beneficial effect on carriage was observed regardless of the strain serogroup. OMV-vaccinated mice also showed reduction of bacterial acquisition of OMV-homolog and hererolog strains in respiratory pathways after intranasal challenge. These results suggest that meningococcal OMV-based vaccines reduce meningococcal carriage and may hence confer herd immunity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 31, Issue 40, 13 September 2013, Pages 4416-4420
Journal: Vaccine - Volume 31, Issue 40, 13 September 2013, Pages 4416-4420
نویسندگان
Valérie Delbos, Ludovic Lemée, Jacques Bénichou, Gilles Berthelot, Ala-Eddine Deghmane, Jean-Philippe Leroy, Estelle Houivet, Eva Hong, Muhamed-Kheir Taha, François Caron, on behalf of the B14 STOP study group on behalf of the B14 STOP study group,