Characterization of chemically defined poly-N-isopropylacrylamide based copolymeric adjuvants

- Isopropyl with an amide in PNiPAAm is responsible for its adjuvant potential.
- Hydrophobic/hydrophilic balance determines adjuvant activity.
- Dual responsive polymers with collagen can induce an autoimmune response.
- Boronate polymer with collagen, induced arthritis in the presence of fructose.
- Continuous release of the polymer bound antigen is essential for adjuvant function.