کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10966305 | 1102775 | 2013 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Quadrivalent HPV vaccine efficacy against disease related to vaccine and non-vaccine HPV types in males
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
A small number of HPV types are related to a majority of HPV-related neoplastic lesions in humans. High-risk types such as HPV 16 and 18 are most often implicated, although other oncogenic and non-oncogenic HPV types can cause disease in men. The efficacy of the quadrivalent HPV vaccine (qHPV) against external genital lesions and intra-anal disease related to HPV in men has been demonstrated. This report examines the vaccine's efficacy against disease due to 10 additional non-vaccine HPV types, as well as efficacy regardless of HPV detection. The data presented suggest that vaccinating males against HPV 6, 11, 16 and 18 protects them against most vaccine HPV-type related anogenital disease. However, significant efficacy against disease due to non-vaccine HPV types was not seen. In addition, the data do not provide any evidence that vaccination with qHPV vaccine will increase the likelihood of disease caused by non-vaccine types in the short term.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 31, Issue 37, 20 August 2013, Pages 3849-3855
Journal: Vaccine - Volume 31, Issue 37, 20 August 2013, Pages 3849-3855
نویسندگان
Stephen E. Goldstone, Heiko Jessen, Joel M. Palefsky, Anna R. Giuliano, Edson D. Jr., Eftyhia Vardas, Carlos Aranda, Richard J. Hillman, Daron G. Ferris, Francois Coutlee, J. Brooke Marshall, Scott Vuocolo, Richard M. Haupt, Dalya Guris,