Probiotics and colostrum/milk differentially affect neonatal humoral immune responses to oral rotavirus vaccine

► Col/milk supplementation enhanced probiotic fecal shedding in unvaccinated animals. ► Col/milk fed pigs had suppressed IgA HRV antibody responses after 2nd vaccine dose. ► Probiotics enhanced IgA HRV responses in Pro + Vac + Col/milk pigs after 3rd vaccine dose. ► Probiotic colonization in Vac + Pro pigs reduced IgG HRV antibody responses.