Modulation of HIV peptide antigen specific cellular immune response by synthetic α- and β-defensin peptides

► We have investigated the efficacy of defensins to induce cellular immune response. ► We have analyzed T-cell proliferation and CD8+/CD4+ cytolytic property. ► We have also analyzed Th1/Th2 cytokine and β-chemokine production. ► Defensins might be responsible for the induction of cell mediated immunity. ► Defensins have a potential role as mucosal adjuvant.