Immune enhancing properties of the novel Matrix-M™ adjuvant leads to potentiated immune responses to an influenza vaccine in mice

► Mice received Matrix-M™, AS03, Alum or FCA, spleen, lymph nodes, and serum were analyzed. ► Immune response compared after vaccination with adjuvanted influenza antigen. ► Matrix-M™ activates innate immune cells, not seen by other investigated adjuvants. ► Splenocyte re-stimulation shows enhanced cytokine response in Matrix-M™ treated mice. ► High antibody levels in mice injected with Matrix-M™- or AS03-adjuvanted vaccine.