Bovine coronaviruses from the respiratory tract: Antigenic and genetic diversity

► This initial U.S. study examined genetic and antigenic differences among BoCV. ► Two clades were identified, BoCV1 and BoCV2 using viral DNA sequencing. ► Three subclades of BoCV2 were identified: BoCV2a, BoCV2b, and BoCV2c. ► Antigenic differences among BoCV clades were detected by viral neutralization tests.