How cost effective is universal varicella vaccination in developing countries? A case-study from Colombia

► This study models the impact of varicella vaccination in the Colombian population. ► Mass vaccination against varicella is cost-effective in Colombia from the third-payer perspective. ► Uncertainty of varicella vaccine impact on Herpes-zoster may change cost effectiveness results. ► Developing countries similar to Colombia with high varicella case-fatality rates may benefit from results of our study.