Comparison of clinical grade type 1 polarized and standard matured dendritic cells for cancer immunotherapy

► Standard and type 1 polarized DCs were compared for use in cancer immunotherapy. ► Type 1 polarized DCs (αDC1 and mDC) induced superior T cell functionality. ► CCR7-dependent migration of type 1 polarized DCs was influenced by autocrine CCL19. ► Maturation with MPLA, IFN-γ and PGE2 (mpDC) proved to be less optimal.