Live oral typhoid vaccine Salmonella Typhi Ty21a - A surrogate vaccine against non-typhoid salmonella?

► There are no vaccines available against non-typhoid Salmonella (NTS). ► Intestinal antibodies against O-antigens have proven protective in animal studies. ► Oral typhoid vaccine Ty21a effectively elicits intestinal antibodies to O-antigens. ► These antibodies cross-react with common NTS strains, such as Salmonella Enteritidis. ► Ty21a may have cross-protective efficacy against numerous NTS strains.