Design and immunological properties of Helicobacter pylori glycoconjugates based on a truncated lipopolysaccharide lacking Lewis antigen and comprising an α-1,6-glucan chain

► We investigate vaccine potential of Helicobacter pylori lipopolysaccharide. ► Conjugation methodology is devised. ► Accessibility and conservation of the α-1,6-glucan core epitope is ensured. ► Glycoconjugates are immunogenic and induce strong and specific IgG responses. ► Broadly cross-reactive bactericidal antibodies are generated.