کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10967394 | 1102828 | 2013 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Long-term safety assessment of live attenuated tetravalent dengue vaccines: Deliberations from a WHO technical consultation
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کلمات کلیدی
PBMCADEDENVSAEAntibody-dependent enhancement - افزایش وابسته به آنتی بادیVaccine safety - ایمنی واکسنWorld Health Organization - سازمان بهداشت جهانیperipheral blood mononuclear cells - سلول های تک هسته ای خون محیطیSerious adverse event - عوارض جانبی جدیDengue vaccine - واکسن دنگDengue virus - ویروس دنگیWHO - که
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Long-term safety assessment of live attenuated tetravalent dengue vaccines: Deliberations from a WHO technical consultation Long-term safety assessment of live attenuated tetravalent dengue vaccines: Deliberations from a WHO technical consultation](/preview/png/10967394.png)
چکیده انگلیسی
Dengue is a rapidly growing public health threat with approximately 2.5Â billion people estimated to be at risk. Several vaccine candidates are at various stages of pre-clinical and clinical development. Thus far, live dengue vaccine candidates have been administered to several thousands of volunteers and were well-tolerated, with minimal short-term safety effects reported in Phase I and Phase II clinical trials. Based on the natural history of dengue, a theoretical possibility of an increased risk of severe dengue as a consequence of vaccination has been hypothesized but not yet observed. In October 2011, the World Health Organization (WHO) convened a consultation of experts in dengue, vaccine regulation and vaccine safety to review the current scientific evidence regarding safety concerns associated with live attenuated dengue vaccines and, in particular, to consider methodological approaches for their long-term evaluation. In this paper we summarize the scientific background and methodological considerations relevant to the safety assessment of these vaccines. Careful planning and a coordinated approach to safety assessment are recommended to ensure adequate long-term evaluation of dengue vaccines that will support their introduction and continued use.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 31, Issue 23, 28 May 2013, Pages 2603-2609
Journal: Vaccine - Volume 31, Issue 23, 28 May 2013, Pages 2603-2609
نویسندگان
Live Dengue Vaccines Technical Consultation Reporting Group Live Dengue Vaccines Technical Consultation Reporting Group, Adwoa D. Bentsi-Enchill, Julia Schmitz, Robert Edelman, Anna Durbin, John T. Roehrig, Peter G. Smith, Joachim Hombach, Jeremy Farrar,