Seroprevalence of seven high-risk HPV types in The Netherlands

► Pre-HPV vaccine antibody levels serve as baseline to evaluate long-term HPV vaccination effects. ► The increase in HPV seroprevalence in adolescents correlates with sexual debut, mainly for HPV16 in women. ► 10% of the population was found seropositive for multiple HPV serotypes. ► Ethnicity, marital status, casual partnership or having a STD increased the risk of HPV seropositivity.