Enhanced immune response induced by a potential influenza A vaccine based on branched M2e polypeptides linked to tuftsin

► Branched peptide embracing four M2e linked to tuftsin was synthesized successfully. ► (M2e)4-G4 can induce a stronger humoral and cellular immune response in mice. ► After vaccination, (M2e)4-G4 can give better protection against viral challenge.