Rapid reduction in invasive pneumococcal disease after introduction of PCV7 into the National Immunization Plan in Israel

► A prospective nationwide IPD surveillance has been conducted in Israeli children for >20 years. ► IPD incidence rapidly declined in children <5 years old following PCV7 introduction. ► No serotype replacement was observed so far. ► Our results compare favorably with other programs, using either 3 + 1 or 2 + 1 regimens. ► PCV13 introduction into the NIP could lead to a further decrease in IPD rates.