CD40 triggering induces strong cytotoxic T lymphocyte responses to heat-killed Staphylococcus aureus immunization in mice: A new vaccine strategy for staphylococcal mastitis

► CD40 engagement boosts cytotoxic responses to intramammary inoculated antigens in mice. ► This vaccine approach reduces the severity of subsequent S. aureus mastitis in mice. ► This strategy shows promise for vaccination against bovine staphylococcal mastitis.