Multivalent fusion protein vaccine for lymphatic filariasis

► Endemic normals carried circulating antibodies against HSP12.6, ALT-2 and TSP. ► These antibodies are involved in killing of B. malayi L3 in ADCC assay. ► Vaccination trials in mice showed >95% protection with rBmHAT. ► rBmHAT vaccination elicited both Th1 and Th2 mixed type immune response.