Active surveillance for influenza vaccine adverse events: The integrated vaccine surveillance system

► Conducted a pilot study of a system to monitor adverse events following immunization (AEFIs) for influenza. ► Vaccinees used IVR, internet or CATI to provide daily reports on AEFIs. ► Vaccinee data were available real-time through a dedicated secure website. ► 90% of vaccinees made one or more daily reports, 49% reported for full 14-day pilot. ► Offering multiple modes of reporting encourages high response rates, and the system exhibited the emerging safety profile of the season's vaccine.