Quantitative comparison of the cross-protection induced by tick-borne encephalitis virus vaccines based on European and Far Eastern virus subtypes

► Use of an unbiased test system for quantitative comparison of TBE vaccines. ► Efficacy against TBE viruses of Far Eastern and European suptypes was tested. ► Comparable neutralization titers induced by different vaccines in mouse model. ► Comparable protection from disease induced by different vaccines in mouse model. ► These data indicate equal protection provided by different vaccines tested.