Antigen-loaded dissolving microneedle array as a novel tool for percutaneous vaccination

► We fabricated antigen-loaded dissolving microneedle array (dMNA) using chondroitin sulfate as a base. ► The dMNAs penetrated, dissolved and released the antigen into the skin of mice, and then induced antigen-specific antibody responses efficiently. ► Antigen-loaded dMNA is a promising antigen-delivery system for percutaneous vaccination.