Intradermal delivery for vaccine dose sparing: Overview of current issues

► Intradermal delivery can enable dose sparing with some vaccines. ► Novel delivery devices may enable safer, more reliable intradermal delivery. ► Novel intradermal delivery devices may also enable vaccine dose sparing. ► Some clinical data show the potential of dose sparing via the intradermal route. ► Many challenges remain before the benefits of intradermal delivery can be realized.