Evaluation of replication, immunogenicity and protective efficacy of a live attenuated cold-adapted pandemic H1N1 influenza virus vaccine in non-human primates

► The 2009 pH1N1 virus replicates to higher titer in rhesus macaques than AGMs. ► The live attenuated pH1N1 influenza virus vaccine is immunogenic in rhesus macaques. ► The pH1N1 LAIV protects rhesus macaques from wild-type virus challenge.