Persistence of long-term immunity to hepatitis B among adolescents immunized at birth

► We examined lasting hepatitis B vaccine-induced immunity in high endemic areas. ► Most at birth vaccinated adolescents protected for up to 15 years. ► Strong response to primary hepatitis B vaccination predicted lasting immune memory. ► However, ∼30% were unable to mount immune response to boosting and may be at risk. ► Revaccination may be needed when opportunities for hepatitis B virus exposures exist.