DNA immunization with HBsAg-based particles expressing a B cell epitope of amyloid β-peptide attenuates disease progression and prolongs survival in a mouse model of Alzheimer's disease

► Can vaccine for Alzheimer's disease (AD) be effective at the onset of the disease? ► Vaccine use in old mice ameliorates cognitive AD impairments. ► Vaccine provides survival benefit and prolongs life span of AD mice.